Click CC on the player to select the subtitle in your language - Dr. Lufino\'s talk for BabelFAmily about gene therapy for Friedreich\'s ataxia. Cervia, Italy, October 2, 2010

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 7 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 6 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 5 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 4 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 3 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 2 of 7

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 1 of 7

Part 1 of 2 of Dr. Massimo Pandolfo\\\'s presentation given on September 25th 2009 at the euro-ATAXIA scientific meeting of Valladolid, Spain, on histone deacetylase inhibitors (HDACi) current state of investigation for Friedreich\\\'s ataxia.

Check out this video of the Three Keys For Confidence while dealing with FA. See you in Philly on November 14, 2009!

Kyle Bryant has Friedreich\'s Ataxia, a fatal progressive neuromuscular disease. In June 2010, Kyle, his recumbent tricycle, and a team of cyclists will compete in the Race Across America to raise awareness for the disease, riding over 3,000 miles in 9 days. The Ataxian is a unique look at Kyle\'s journey as an individual dealing with a degenerative, life shortening disease. Oh, and don\'t forget embarking on a grueling adventure in the form of one of the hardest bike races in the world, a ride not even Lance Armstrong has undertaken. Welcome to the fight for a cure. [More] [Less]

Part 1 of 3 Dr. Pierre Rustins presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES. Pioglitazone in Friedreichs Ataxia: why and how?

Click CC on the player to select the subtitle in your language - BabelFAmily\'s interview with Ron Bartek on the latest progress in Friedreich\'s ataxia research. Cervia, Italy, October 2, 2010 - part 1 of 7

Part 2 of 2 of Dr. Massimo Pandolfo\\\\\\\'s presentation given on September 25th 2009 at the euro-ATAXIA scientific meeting of Valladolid, Spain, on histone deacetylase inhibitors (HDACi) current state of investigation for Friedreich\\\\\\\'s ataxia.

Part 3 of 3 Dr. Pierre Rustin\'s presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES: Pioglitazone in Friedreichs Ataxia: why and how?.

Dr. S. Adinolfis presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES. Frataxin is the gatekeeper of Fe-S cluster formation. Dr. Salvatore Adinolfi, Annalisa Pastores team. Iron-sulfur cluster formation is an essential and yet poorly understood metabolic pathway common to all living organisms. Frataxin, an essential and highly conserved mitochondrial protein whose reduced expression causes Friedreich\'a Ataxia (FRDA or FA) in humans, has been described as an iron chaperone which provides iron in iron-sulfur cluster assembly. We have tested this hypothesis using a bacterial model and different biochemical and molecular biology techniques. We could show that CyaY, the bacterial orthologue of frataxin, intervenes in iron-sulfur (Fe-S) cluster assembly not simply as an iron donor. Through binding to the desulfurase IscS with a 1:1 stoichiometry and micromolar affinity, frataxin acts as an iron concentration dependent inhibitor of cluster formation. This suggested that frataxin is an iron sensor which acts as the gate keeper for Fe-S cluster formation and fine tunes the quantity of Fe-S clusters formed to the concentration and/or possibly the distribution of the available acceptors. Our observations provide a new perspective for understanding FRDA and a mechanistic model which rationalizes the available knowledge. Source: euro-Ataxia meeting 2009/FEDAES [More] [Less]

A music video focusing mainly on the characters of Georgia and Beagle, from the movie \"The Cake Eaters\", the directorial debut from actress Mary Stuart Masterson. Kristen Stewart did an amazing job in this movie, playing Georgia, who has Friedreich\'s Ataxia. The song is \"Begin\" by The Wailin\' Jennys. [More] [Less]

Chandu George and Nirmala both FAers being interveiwed by Indian local Media,George leader of SEEK A MIRACLE ATAXIA GROUP, India, Speaking about Ataxia and raising awareness about Ataxia in Indian society,and promoting Ataxia\'s cause which is never heard much in India to the patients, their family members,carers and society, Most of the programme is spoken in Local indian language \'TELUGU\' [More] [Less]

Chandu George and Nirmala both FAers being interveiwed by Indian local Media,George leader of SEEK A MIRACLE ATAXIA GROUP, India, Speaking about Ataxia and raising awareness about Ataxia in Indian society,and promoting Ataxia\'s cause which is never heard much in India to the patients, their family members,carers and society, Most of the programme is spoken in Local indian language \'TELUGU\'-In this part of video is spoken by Vijaya Nirmala of SAMAG. [More] [Less]

Part 2 of 2 of Dr. Massimo Pandolfo\\\\\\\'s presentation given on September 25th 2009 at the euro-ATAXIA scientific meeting of Valladolid, Spain, on histone deacetylase inhibitors (HDACi) current state of investigation for Friedreich\\\\\\\'s ataxia.

Dr. S. Adinolfis presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES. Frataxin is the gatekeeper of Fe-S cluster formation. Dr. Salvatore Adinolfi, Annalisa Pastores team. Iron-sulfur cluster formation is an essential and yet poorly understood metabolic pathway common to all living organisms. Frataxin, an essential and highly conserved mitochondrial protein whose reduced expression causes Friedreich\'a Ataxia (FRDA or FA) in humans, has been described as an iron chaperone which provides iron in iron-sulfur cluster assembly. We have tested this hypothesis using a bacterial model and different biochemical and molecular biology techniques. We could show that CyaY, the bacterial orthologue of frataxin, intervenes in iron-sulfur (Fe-S) cluster assembly not simply as an iron donor. Through binding to the desulfurase IscS with a 1:1 stoichiometry and micromolar affinity, frataxin acts as an iron concentration dependent inhibitor of cluster formation. This suggested that frataxin is an iron sensor which acts as the gate keeper for Fe-S cluster formation and fine tunes the quantity of Fe-S clusters formed to the concentration and/or possibly the distribution of the available acceptors. Our observations provide a new perspective for understanding FRDA and a mechanistic model which rationalizes the available knowledge. Source: euro-Ataxia meeting 2009/FEDAES [More] [Less]

Part 2 of 3 Dr. Pierre Rustin\'s presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES. Pioglitazone in Friedreichs Ataxia: why and how? .

Part 1 of 3 Dr. Pierre Rustins presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES. Pioglitazone in Friedreichs Ataxia: why and how?

Part 3 of 3 Dr. Pierre Rustin\'s presentation given on September 25th 2009 at the euro-Ataxia scientific meeting of Valladolid, Spain, organized by FEDAES: Pioglitazone in Friedreichs Ataxia: why and how?.

Check out this video of the Three Keys For Confidence while dealing with FA. See you in Philly on November 14, 2009!